| Publication Title : | Tridax procumbens leaf extract potentiation of duodenal and jejunal contraction: a possible role for M_3 and H_1 receptors, K_CA , K_it and K_CA channels |
| Author(s) : | Salami Shakiru A., Salahdeen Hussein M, Onakoya Oluwasegun A, Murtala Babatunde A |
| Abstract : | Objective: Despite medicinal and nutritional prospects of Tridax procumbens leaf, contractile functions of aqueous Tridax procumbens leaf extract (ATPLE) on small intestinal smooth muscle have not been investigated. This study investigates the contractile activity of the duodenum and jejunum after ATPLE consumption. Results: Cumulative doses of acetylcholine (10-9-10-5 M), histamine (10-9-10-5 M) and potassium (10-50 mM) significantly increased (p<0.05) contraction in duodenal and jejunal strips of ATPLE treated group. Extracellular Ca2+ influx significantly increased contraction in duodenal strips of ATPLE treated while jejunal strips contractions were significantly reduced. Incubation of duodenal and jejunal strips in atropine, L-NAME, and indomethacin significantly increased contraction in ATPLE treated group. Incubation in nifedipine restrained contraction in the duodenum but significantly increased contraction in the jejunum of ATPLE treated group. Incubation in glibenclamide significantly inhibited contractions in the jejunum of ATPLE treated. Conclusion: ATPLE potentiation of contractile functions in the duodenum and jejunum was not impaired by competitive M receptor inhibition, nitric oxide synthase inhibition, K channel activation, calcium influx, 3 CA and activation of H receptor. However, K mediated contractions were substantially inhibited. 1 ATP Phytochemically active constituents of ATPLE may play roles for the contractile activity. |
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